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. 1977 Jun 4;1(8023):1169-71.
doi: 10.1016/s0140-6736(77)92714-3.

Isolation of reovirus-like agents from patients with Crohn's disease

P J Whorwell, C A Phillips, W L Beeken, P K Little, K D Roessner

Isolation of reovirus-like agents from patients with Crohn's disease

P J Whorwell et al. Lancet. .

Abstract

220 nm filtrates of intestinal resections from 6 of 10 patients with Crohn's disease produced a cytopathic effect in WI-38 tissue-culture monolayers, whereas controls had no effect. Characterisation of the virus responsible has been completed in 3 of the 6 positive isolates and indicates that it is an R.N.A. virus, 55-60 nm in diameter, heat, ether, and acid stable, and antigenically related to Nebraska calf-diarrhoea virus. It therefore belongs to the Reoviridae family.

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