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. 1983 Apr;46(1):288-92.
doi: 10.1128/JVI.46.1.288-292.1983.

Molecular cloning and analysis of the endogenous retrovirus chemically induced from RFM/Un mouse cell cultures

R S Liou, L R Boone, J O Kiggans, D M Yang, T W Wang, R W Tennant, W K Yang

Molecular cloning and analysis of the endogenous retrovirus chemically induced from RFM/Un mouse cell cultures

R S Liou et al. J Virol. 1983 Apr.

Abstract

We molecularly cloned and analyzed an N-tropic ecotropic retrovirus induced with iododeoxyuridine from RFM/Un mouse cell cultures. Based on the restriction map, the RFM/Un virus appears to be indistinguishable from other induced N-tropic retroviruses. A nucleotide sequence analysis of the long terminal repeat of an infectious clone revealed structural features characteristic of murine type C retrovirus long terminal repeats. The U3 region of the RFM/Un virus long terminal repeat, however, contained no short sequence duplication or insertion found in other murine leukemia virus isolates.

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