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. 1983 Mar 18;219(4590):1327-9.
doi: 10.1126/science.6828859.

Role of surface-active phospholipids in gastric cytoprotection

L M Lichtenberger, L A Graziani, E J Dial, B D Butler, B A Hills

Role of surface-active phospholipids in gastric cytoprotection

L M Lichtenberger et al. Science. .

Abstract

Intragastric administration of a liposomal surfactant suspension markedly reduced acid-induced gastric ulcerogenesis and bleeding in rats. The concentration of surface-active molecules intrinsically present in the gastric mucosa was increased two to six times by administration of 16,16-dimethyl prostaglandin E2. Thus, local accumulation of surface-active phospholipids may be an integral component of the cytoprotective mechanism activated by prostaglandin treatment.

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