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Comparative Study
. 1978 Jun 16;4(2):87-92.
doi: 10.1007/BF00775966.

Effect of biotin on phosphorylation, acetylation, methylation of rat liver histones

F Petrelli, S Coderoni, P Moretti, M Paparelli
Comparative Study

Effect of biotin on phosphorylation, acetylation, methylation of rat liver histones

F Petrelli et al. Mol Biol Rep. .

Abstract

Biotin deficient rat liver histones showed decreased phosphorylation and methylation, and increased acetylation rates as compared to normal rat liver histones: these alterations may be related to the observed lower stability of the interactions between histones and DNA. The modifications of the metabolic process might be the consequence of an alteration of the synthesis of the enzymes involved in histone phosphorylation, acetylation and methylation mechanisms and are presumably related to a biotin effect upon the synthesis of RNA and proteins.

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