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. 1983 Feb 11;272(2):227-32.
doi: 10.1016/s0378-4347(00)86124-1.

Ischemic change of organic acids in kidney

T Niwa, N Yamamoto, H Asada, A Kawanishi, M Yokoyama, K Maeda, T Ohki

Ischemic change of organic acids in kidney

T Niwa et al. J Chromatogr. .

Abstract

Organic acids in rabbit renal tissue biopsy were analyzed by capillary column gas chromatography--mas s spectrometry. The change of these organic acids under ischemic conditions was determined over 60 min after clamping the renal artery and vein. The results showed that lactic acid, glycolic acid, 2-hydroxybutyric acid, 3-hydroxypropionic acid, 2-methyl-glyceric acid, glyceric acid and malic acid increased at 4 and 6 min after clamping, but then decreased at 15 min. Glycerol increased 2 min after clamping and then decreased. However, 3-deoxyaldonic acids of 3-deoxytetronic acid, 3-deoxy-2-C-hydroxymethyltetronic acid and 3-deoxypentonic acid decreased in the renal tissue biopsy from 2 min after clamping.

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