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. 1983 Apr;26(4):611-3.
doi: 10.1021/jm00358a032.

Antimycotic azoles. 6. Synthesis and antifungal properties of terconazole, a novel triazole ketal

J Heeres, R Hendrickx, J Van Cutsem

Antimycotic azoles. 6. Synthesis and antifungal properties of terconazole, a novel triazole ketal

J Heeres et al. J Med Chem. 1983 Apr.

Abstract

The preparation and antifungal properties of cis-1-[4-[[2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1, 3-dioxolan-4-yl]methoxy]phenyl]-4-(1-methylethyl)piperazine are reported. Terconazole has a high topical in vivo activity against vaginal candidosis in rats and against dermatophytosis in guinea pigs.

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