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. 1983 Apr 11;32(15):1779-84.
doi: 10.1016/0024-3205(83)90842-1.

In vitro block of murine L 1210 leukemia cell growth by amiloride, an inhibitor of passive Na+ influx

C Pieri, S Giunta, C Giuli, C Bertoni-Freddari, M Muzzioli

In vitro block of murine L 1210 leukemia cell growth by amiloride, an inhibitor of passive Na+ influx

C Pieri et al. Life Sci. .

Abstract

The present study was aimed to decide whether Na+ influx can be involved in regulation of murine L 1210 leukemia cell growth. Cells were cultivated in the presence of different concentrations of amiloride and cellular growth was monitored by 3H-thymidine incorporation/10(5) cells. This drug inhibited cell growth in concentrations ranging from 1 X 10(-5) to 1 X 10(-3) mmol/ml. Even short time treatments with amiloride caused irreversible alterations: the cells, although survived, lost their ability to divide. The results support the hypothesis that Na+ influx is necessary for the duplication of tumor cells.

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