doi: 10.1016/0006-291x(83)91277-9.
Structure and location of asparagine-linked oligosaccharides in the Fc region of A human immunoglobulin D
- PMID: 6838507
- DOI: 10.1016/0006-291x(83)91277-9
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Structure and location of asparagine-linked oligosaccharides in the Fc region of A human immunoglobulin D
Biochem Biophys Res Commun.
.
Abstract
Seven kinds of asparagine-linked oligosaccharides were bound to the Fc region of a human immunoglobulin D(NIG-65). The oligosaccharides quantitatively released from four species of glycopeptides by digestion with almond glycopeptidase, were separated by Bio-Gel p-4 column chromatography and were purified further by thin-layer chromatography. The sugars were identified with GC-MS following the permethylation of respective oligosaccharide. To Asn-68 (NIG-65 Fc numbering (1)), two kinds of high-mannose-type oligosaccharides were bonded. To Asn-159, a kind of hybride-type and two kinds of bisected complex-type oligosaccharides were attached. From Asn-210, four kinds of bisected complex-type oligosaccharides were isolated.
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