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. 1983 Mar 14;263(1):172-6.
doi: 10.1016/0006-8993(83)91217-9.

Radial maze performance in three strains of mice: role of the fimbria/fornix

Radial maze performance in three strains of mice: role of the fimbria/fornix

D K Reinstein et al. Brain Res. .

Abstract

Three strains of mice were tested on an 8-arm radial maze, an index of hippocampus-dependent spatial memory. Levels of performance differed between strains with C57Br/cj greater than Balb/cj greater than C57Bl/6j. Lesions of the fimbria/fornix disrupted performance in the C57Br and Balb strains: the C57Bl mice never performed better than chance before or after surgery. Choline acetyltransferase activity in hippocampus was not correlated with radial maze performance. These findings suggest a possible genetic contribution towards radial maze behavior.

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