[Study of the insulin-receptor interaction on the plasma membranes of rat liver]
[Article in
Russian]
- PMID: 683973
Item in Clipboard
[Study of the insulin-receptor interaction on the plasma membranes of rat liver]
[Article in
Russian]
Probl Endokrinol (Mosk).
1978 Jul-Aug.
Abstract
The radioreceptor method was applied to the study of specific insulin binding on the plasma membranes of the rat liver. Highly purified plasma membranes were obtained and conditions of their incubation with insulin were worked out for this purpose. Two types of insulin receptors were revealed: the first one with Cass=3.8( +/- 0.4)x10(11)M-1 and binding capacity=0.7( +/- 0.1) pM/mg; the second one--with less relationship of Cass=8( +/- 1)x10(10)M-1 and binding capacity=5( +/- 0.7) pM/mg.
Similar articles
-
[Interaction of insulin and its receptors in the muscles: specific I125 binding with plasma membranes of the skeletal muscle of rat].Probl Endokrinol (Mosk). 1979 May-Jun;25(3):57-62. Probl Endokrinol (Mosk). 1979. PMID: 461385 Russian.
-
[Insulin binding by receptors of the plasma membranes of the liver in hens in ontogenesis].Ontogenez. 1988 Jan-Feb;19(1):55-8. Ontogenez. 1988. PMID: 3285282 Russian.
-
Effect of hypothermia on the insulin--receptor interaction in liver plasma membranes.J Physiol Pharmacol. 1993 Dec;44(4):399-408. J Physiol Pharmacol. 1993. PMID: 8123887
-
Internalization of polypeptide hormones: mechanism, intracellular localization and significance.Diabetologia. 1980 Apr;18(4):263-74. doi: 10.1007/BF00251003. Diabetologia. 1980. PMID: 6998797 Review. No abstract available.
-
Radiolabeled hormones in insulin research, a minireview.J Labelled Comp Radiopharm. 2020 Dec;63(14):576-581. doi: 10.1002/jlcr.3881. Epub 2020 Oct 8. J Labelled Comp Radiopharm. 2020. PMID: 32909277 Review.