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. 1983;63(2):191-2.
doi: 10.1007/BF00291544.

Incidence of chromosomal aberrations in patients under combined tuberculostatic chemotherapy

I C Roman, E Vainer, I Socosan, T Drăghicescu

Incidence of chromosomal aberrations in patients under combined tuberculostatic chemotherapy

I C Roman et al. Hum Genet. 1983.

Abstract

Chromosome studies were carried out on the peripheral blood lymphocytes of ten tuberculosis (tb) patients receiving combined tuberculostatic chemotherapy for long intervals (3-10 months) and on those of two control groups, one of ten healthy subjects and the second of ten other tb patients in whom the tuberculostatic treatment had been discontinued 10-19 months previously. An increased proportion of aberrations, particularly chromosomal breaks and achromatic gaps, were observed in the patients under treatment, suggesting a possible synergic interaction of INH and RMA in the production of chromosomal damage.

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