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. 1978 Sep 1;201(4358):835-7.
doi: 10.1126/science.684411.

Vitamin D: two dihydroxylated metabolites are required for normal chicken egg hatchability

H L Henry, A W Norman

Vitamin D: two dihydroxylated metabolites are required for normal chicken egg hatchability

H L Henry et al. Science. .

Abstract

When hens are raised to sexual maturity from hatching with 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] as their sole source of cholecalciferol (vitamin D3), fertile eggs appear to develop normally but fail to hatch. When hens receive a combination of 1,25(OH)2D3 and 24R,25-dihydroxyvitamin D3 [24,25(OH)2D3], hatchability equivalent to that with hens given vitamin D3 is obtained. These results suggest a biological role for 24,25(OH)2D3 not previously recognized.

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