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. 1983 Jun 3;220(4601):1055-7.
doi: 10.1126/science.6844925.

DNA methylation decreases in aging but not in immortal cells

V L Wilson, P A Jones

DNA methylation decreases in aging but not in immortal cells

V L Wilson et al. Science. .

Abstract

When normal diploid fibroblasts from mice, hamsters, and humans were grown in culture, the 5-methylcytosine content of their DNA's markedly decreased. The greatest rate of loss of 5-methylcytosine residues was observed in mouse cells, which survived the least number of division. Immortal mouse cell lines had more stable rates of methylation.

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