Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1983 Mar;6(1):77-81.
doi: 10.1111/j.1365-2885.1983.tb00458.x.

Placental transfer and renal clearance of sulphamethoxazole and its metabolite N4-acetylsulphamethoxazole in a pregnant ewe

T B Vree, J J Reekers-Ketting, J F Nouws, T H Arts

Placental transfer and renal clearance of sulphamethoxazole and its metabolite N4-acetylsulphamethoxazole in a pregnant ewe

T B Vree et al. J Vet Pharmacol Ther. 1983 Mar.

Abstract

Sulphamethoxazole and its metabolite, N4-acetylsulphamethoxazole, were shown to cross the placenta of a pregnant ewe. The plasma concentration of N4-acetylsulphamethoxazole increased in the foetus due to the limited elimination properties of the immature kidney. The amniotic fluid concentration of sulphamethoxazole and N4-acetylsulphamethoxazole were low, amounting to 2.0 and 0.46 micrograms/ml respectively. Protein binding of the sulphonamides was slightly higher in the foetus than in the ewe.

PubMed Disclaimer

Substances

LinkOut - more resources