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. 1983 Feb 21;35(2):161-6.
doi: 10.1016/0304-3940(83)90544-x.

Total GABA and homocarnosine in CSF as indices of brain GABA concentrations

Total GABA and homocarnosine in CSF as indices of brain GABA concentrations

M G Palfreyman et al. Neurosci Lett. .

Abstract

Treatment of rats with gamma-vinyl-GABA, an inhibitor of GABA-transaminase, caused a dose- and time-related increase in brain GABA concentrations concomitant with increases in the concentrations of total GABA and homocarnosine in the CSF. At 18 h after treatment both CSF parameters correlated significantly with brain GABA concentrations. However, only total GABA in CSF accurately reflected brain GABA concentrations as a function of time after treatment and is therefore the preferred index.

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