Total GABA and homocarnosine in CSF as indices of brain GABA concentrations
- PMID: 6856194
- DOI: 10.1016/0304-3940(83)90544-x
Total GABA and homocarnosine in CSF as indices of brain GABA concentrations
Abstract
Treatment of rats with gamma-vinyl-GABA, an inhibitor of GABA-transaminase, caused a dose- and time-related increase in brain GABA concentrations concomitant with increases in the concentrations of total GABA and homocarnosine in the CSF. At 18 h after treatment both CSF parameters correlated significantly with brain GABA concentrations. However, only total GABA in CSF accurately reflected brain GABA concentrations as a function of time after treatment and is therefore the preferred index.
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