[Ultrastructural changes in capillaries of the cerebral cortex during ischemia]

Abstract

Electron microscopic studies of dynamic capillary changes demonstrated a tendency towards a progressive decrease of the diameter or a complete occlusion by thrombs. Acute disorders of microcirculation due to a bilateral ligation of common carotid arteries lead not only to different reactions of the capillaries, but to destructive changes in the capillary endothelium. As a result of the developing ischemia, hypoxia has an important pathogenetical significance in disorders of circulation, inasmuch as it exerts influence not only on the nervous tissue, but on the capillaries leading to their dysfunction, an increase of the wall permeability and oedema. The easily developing oedema in conditions of hypoxia, evokes further lesions of the brain tissue which concerns the ultrastructure of cell elements in the whole system: capillaries, glia, neuron.