doi: 10.1126/science.6857275.
Salicylate and mitochondrial injury in Reye's syndrome
- PMID: 6857275
- DOI: 10.1126/science.6857275
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Salicylate and mitochondrial injury in Reye's syndrome
Science.
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Abstract
Electron microscopic and spectrophotometric studies showed that salicylate causes gross swelling of mitochondria in isotonic salt solutions. In overall morphology the salicylate-treated mitochondria resembled those from patients with Reye's syndrome. Salicylate analogs such as m-hydroxybenzoate, p-hydroxybenzoate, and benzoate did not exert this effect. The mitochondria deformed by salicylate tended to return to their original condensed form on removal of the drug.
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