[Physiological mechanisms of the regulation of lipoprotein biosynthesis in liver during physical exercise and in different phases of the restoration period]

Abstract

Changes in serum lipoprotein pattern and in total content of low density lipoproteins (LDL) and very low density lipoproteins (VLDL) were studied in blood and liver tissues of rats during physical exercise and restoration. Physical training induced synthesis of liver lipoproteins, in particular of their protein components. An initial period of lipoprotein synthesis in the liver tissue was preceded by transient activation of lysosomes in hepatocytes and their translocation towards nuclei. When lysosome translocation was depressed by vinblastine or colchicine injected 1 h before the physical exercise, an increase in total amount of LDL and VLDL fractions in liver and blood could not be observed. The inhibition of lysosomal proteolytic activity by hordox also impaired an increase in blood and liver lipoproteins. The data obtained suggest that activation of lysosomes and their translocation towards nuclei are important for induction of lipoprotein synthesis in liver tissue during physical exercise.