doi: 10.1007/BF00333900.
On the histopathogenesis of rat forestomach carcinoma caused by aristolochic acid
- PMID: 6860143
- DOI: 10.1007/BF00333900
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On the histopathogenesis of rat forestomach carcinoma caused by aristolochic acid
Arch Toxicol.
1983 Mar.
Abstract
The histopathogenesis of rat forestomach carcinoma induced experimentally with aristolochic acid was investigated. The intragastric administration of 10 mg/kg/day caused extensive necrosis of the squamous epithelium, followed by regeneration and hyperplasia, papilloma formation and ultimately by invasive squamous cell carcinoma.
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