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. 1983 Mar;52(3):209-20.
doi: 10.1007/BF00333900.

On the histopathogenesis of rat forestomach carcinoma caused by aristolochic acid

U Mengs

On the histopathogenesis of rat forestomach carcinoma caused by aristolochic acid

U Mengs. Arch Toxicol. 1983 Mar.

Abstract

The histopathogenesis of rat forestomach carcinoma induced experimentally with aristolochic acid was investigated. The intragastric administration of 10 mg/kg/day caused extensive necrosis of the squamous epithelium, followed by regeneration and hyperplasia, papilloma formation and ultimately by invasive squamous cell carcinoma.

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