doi: 10.1016/0006-291x(83)90441-2.
The effect of copper chelating drugs on liver iron mobilization in the adult rat
- PMID: 6860330
- DOI: 10.1016/0006-291x(83)90441-2
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The effect of copper chelating drugs on liver iron mobilization in the adult rat
Biochem Biophys Res Commun.
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Abstract
To test the hypothesis that ferroxidase I (ceruloplasmin) activity is essential for iron mobilization, adult rats were fed a copper sufficient diet with or without the chelating drugs D-penicillamine and triethylenetetramine for 120 days. By day 6 of treatment and for the remainder of the experiment the drug-fed rats showed low plasma copper concentration and low ferroxidase I activity. Plasma ferroxidase II activity in the DPA and TETA groups tended to be slightly lower than that of controls. No animals became anemic. Therefore, persistent low plasma ferroxidase I does not necessarily cause anemia in the adult rat.
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