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. 1983;24(4):529-32.
doi: 10.1007/BF00609898.

Relationships between plasma theophylline clearance, liver volume and body weight in children and adults

J J Grygiel, H Ward, M Ogborne, A Goldin, D J Birkett

Relationships between plasma theophylline clearance, liver volume and body weight in children and adults

J J Grygiel et al. Eur J Clin Pharmacol. 1983.

Abstract

The influence of liver volume and body weight on plasma theophylline clearance was investigated in asthmatic children and adults. A linear relationship (r = +0.99) was demonstrated between ideal body weight and liver volume estimated by an ultrasonic scanning technique. Age-related changes in liver volume-to-body weight ratio could account for only 30% of differences in plasma theophylline clearance (1/h/kg) between children and adults. It is summized that increased hepatic mixed function oxidase activity is the major contributor to the higher plasma theophylline clearance in children.

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