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. 1983 Jul 15;39(7):784-5.
doi: 10.1007/BF01990326.

Formation of the active antifertility metabolite of (S)-alpha-chlorohydrin in boar sperm

A R Jones, D Stevenson

Formation of the active antifertility metabolite of (S)-alpha-chlorohydrin in boar sperm

A R Jones et al. Experientia. .

Abstract

The male antifertility agent (S)-alpha-chlorohydrin (I) is metabolized by boar sperm to (S)-3-chlorolactaldehyde (II) by an enzyme that is involved in the oxidation of glycerol to glyceraldehyde. The presence of glycerol decreases the activity of this enzyme towards (S)-alpha-chlorohydrin in vitro thereby preventing the formation of (S)-3-chlorolactaldehyde, an inhibitor of glyceraldehyde 3-phosphate dehydrogenase in boar sperm.

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References

    1. Xenobiotica. 1975 Mar;5(3):155-65 - PubMed
    1. Contraception. 1980 Nov;22(5):505-12 - PubMed
    1. Aust J Biol Sci. 1982;35(6):595-605 - PubMed
    1. Nature. 1975 May 1;255(5503):75-7 - PubMed
    1. Chem Biol Interact. 1982 Jul 15;41(1):95-104 - PubMed

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