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. 1983 Jul 15;39(7):784-5.
doi: 10.1007/BF01990326.

Formation of the active antifertility metabolite of (S)-alpha-chlorohydrin in boar sperm

A R Jones, D Stevenson

Formation of the active antifertility metabolite of (S)-alpha-chlorohydrin in boar sperm

A R Jones et al. Experientia. .

Abstract

The male antifertility agent (S)-alpha-chlorohydrin (I) is metabolized by boar sperm to (S)-3-chlorolactaldehyde (II) by an enzyme that is involved in the oxidation of glycerol to glyceraldehyde. The presence of glycerol decreases the activity of this enzyme towards (S)-alpha-chlorohydrin in vitro thereby preventing the formation of (S)-3-chlorolactaldehyde, an inhibitor of glyceraldehyde 3-phosphate dehydrogenase in boar sperm.

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