Transfer of delayed hypersensitivity through repeatedly sensitized peritoneal exudate cells during experimental ancylostomiasis in mice

Abstract

Current investigations using sensitized peritoneal exudate cells from mice infected repeatedly with Ancylostoma caninum larvae supply the evidence that these cells have the capability to transfer passive immunity to isogeneic recipients in contrast to normal cells from uninfected donors. High doses of sensitization to donors and a lapse of time between the expansion and proliferation of cells in the recipients provide a rather strong immunological readiness to expel/destroy the worm burden. The larvae bore through the gut reaching the peritoneal cavity but cannot enter the liver and/or lungs; they are thus misled (in the absence of normal guiding influences) to muscles where they undergo allergic death.