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. 1978 Jul;27(4):751-7.
doi: 10.4269/ajtmh.1978.27.751.

The antileishmanial activity of lepidines

K E Kinnamon, E A Steck, P S Loizeaux, W L Hanson, W L Chapman Jr, V B Waits

The antileishmanial activity of lepidines

K E Kinnamon et al. Am J Trop Med Hyg. 1978 Jul.

Abstract

A series of lepidines (6-methoxy-4-methyl-8-aminoquinoline derivatives) was studied in a hamster-Leishmania donovani model. Members of this class were found to have activity many-fold that of the standard, meglumine antimoniate (Glucantime). One of them, 8-(6-diethylamino-hexylamino)-6-methoxy-4-methylquinoline, designated WR 6026, when given orally was over 700 times as effective as the standard antimonial drug.

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