Case Reports
doi: 10.1007/BF00274759.
Familial fragility on chromosome 16 (fra 16q22) enhanced by both interferon and Distamycin A
- PMID: 6862438
- DOI: 10.1007/BF00274759
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Case Reports
Familial fragility on chromosome 16 (fra 16q22) enhanced by both interferon and Distamycin A
Hum Genet.
1983.
Abstract
A family with a "fragile site" at 16q22, inducible by both interferon and Distamycin A, is reported. Immunological problems were found in the family. In a sibship of ten, eight children had died in infancy. Our study led to the conclusions that interferon and Distamycin A induce fragility at the same site, which has the same characteristics as the spontaneous fragile site; that a viral hypothesis for this fragility may be supported; and that immunoincompetence of one kind or another must be considered in families presenting a fragile site at 16q22.
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