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Case Reports
. 1983;63(4):341-4.
doi: 10.1007/BF00274759.

Familial fragility on chromosome 16 (fra 16q22) enhanced by both interferon and Distamycin A

F Shabtai, D Klar, S Bichacho, J Hart, I Halbrecht
Case Reports

Familial fragility on chromosome 16 (fra 16q22) enhanced by both interferon and Distamycin A

F Shabtai et al. Hum Genet. 1983.

Abstract

A family with a "fragile site" at 16q22, inducible by both interferon and Distamycin A, is reported. Immunological problems were found in the family. In a sibship of ten, eight children had died in infancy. Our study led to the conclusions that interferon and Distamycin A induce fragility at the same site, which has the same characteristics as the spontaneous fragile site; that a viral hypothesis for this fragility may be supported; and that immunoincompetence of one kind or another must be considered in families presenting a fragile site at 16q22.

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References

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