Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1983 Jul;36(7):804-7.
doi: 10.1136/jcp.36.7.804.

Plasma spermidine concentrations as early indication of response to therapy in human myeloma

O A Van Dobbenburgh, B Houwen, H Jurjens, J Marrink, M R Halie, H O Nieweg

Plasma spermidine concentrations as early indication of response to therapy in human myeloma

O A Van Dobbenburgh et al. J Clin Pathol. 1983 Jul.

Abstract

Eighteen patients with melphalan refractory myeloma were treated with vindesine and prednisone. Plasma spermidine concentrations were measured by radioimmunoassay before and after a single vindesine injection. Seven patients showed a significant rise of plasma spermidine after vindesine and five of these showed a clinical response on further evaluation. Of the 11 patients who did not show raised spermidine concentrations, 10 did not respond to the therapy. The correlation between clinical response/rise of spermidine and between non-response/no rise of spermidine was statistically significant (p less than 0.05). Pretreatment spermidine concentrations did not distinguish those who responded to treatment nor did they differ in patients and controls.

PubMed Disclaimer

References

    1. Cancer. 1972 Aug;30(2):382-9 - PubMed
    1. Cancer. 1975 Sep;36(3):842-54 - PubMed
    1. Cancer Res. 1977 Jan;37(1):214-21 - PubMed
    1. Biochim Biophys Acta. 1978 Apr 6;473(3-4):241-93 - PubMed
    1. Lancet. 1975 Oct 25;2(7939):797-9 - PubMed