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Case Reports
. 1983 May;8(5):677-9.
doi: 10.1016/s0190-9622(83)70079-4.

Methotrexate-induced necrolysis

K M Reed, A J Sober
Case Reports

Methotrexate-induced necrolysis

K M Reed et al. J Am Acad Dermatol. 1983 May.

Abstract

A 72-year-old woman with a long history of recalcitrant psoriasis developed severe generalized erosions after receiving low-dose (7.5 mg) methotrexate. Her clinical picture was consistent with toxic epidermal necrolysis and showed a gradual response to systemic steroids and topical therapy. Patients with underlying dermatoses or previous cutaneous insults may be particularly prone to adverse cutaneous reactions resulting from folic acid antagonists.

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