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. 1983 Jul 1;158(1):258-63.
doi: 10.1084/jem.158.1.258.

Complement receptor mediates enhanced flavivirus replication in macrophages

M J Cardosa, J S Porterfield, S Gordon

Complement receptor mediates enhanced flavivirus replication in macrophages

M J Cardosa et al. J Exp Med. .

Abstract

Evidence is presented that M phi complement receptors (CR3) mediate IgM-dependent enhancement of flavivirus replication in the presence of complement. Enhancement is blocked by pretreatment of macrophages with monoclonal antibody Ml/70, which inhibits CR3 binding, but not by pretreatment with monoclonal antibody 2.4G2, which inhibits FcR binding.

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