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. 1983 Jun 25;11(12):4141-55.
doi: 10.1093/nar/11.12.4141.

Heteronomous DNA

S Arnott, R Chandrasekaran, I H Hall, L C Puigjaner
Free PMC article

Heteronomous DNA

S Arnott et al. Nucleic Acids Res. .
Free PMC article

Abstract

A fibrous form of poly d(A):poly d(T) has a heteronomous secondary structure which is the first to be confirmed for a polynucleotide duplex: although both chains are 10(1) helices, mutually hydrogen-bonded in the standard (Watson-Crick) fashion, each has a quite different conformation. One chain -- probably poly d(A) -- has C3'-endo-puckered furanose rings characteristic of the A family of polynucleotide secondary structures while the other -- probably poly d(T) -- has the C2'-endo-puckered rings of the B family. Since analogous heteronomous structures could be assumed by DNA-DNA or DNA-RNA duplexes containing more general base sequences the polymorphic range of polynucleotide double-helices may be even greater than we have come to suppose.

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