doi: 10.1007/BF01851120.
A new model for testing therapeutic interventions during myocardial ischemia
- PMID: 6867478
- DOI: 10.1007/BF01851120
Item in Clipboard
A new model for testing therapeutic interventions during myocardial ischemia
Res Exp Med (Berl).
1983.
Abstract
An open-chest dog heart model is presented which shows highly reproducible hemodynamic, electrophysiologic, and metabolic changes during and after short-term coronary occlusions. We repeatedly performed 3-min coronary ligations of the proximal ramus interventricularis anterior followed by reperfusion periods of 45 min. Thus, hemodynamic, metabolic, and electrophysiologic parameters of myocardial damage were fully reversible. The experimental model presented seems well suited to evaluate interventions which aim at influencing the extent and damage of myocardial ischemia without needing a large number of separate experiments.
Similar articles
-
Postischemic myocardial "stunning". Identification of major differences between the open-chest and the conscious dog and evaluation of the oxygen radical hypothesis in the conscious dog.Circ Res. 1991 Sep;69(3):731-47. doi: 10.1161/01.res.69.3.731. Circ Res. 1991. PMID: 1873868
-
Disparity of reperfusion arrhythmias after reversible myocardial ischemia in open chest and conscious dogs.J Am Coll Cardiol. 1986 May;7(5):1047-56. doi: 10.1016/s0735-1097(86)80222-4. J Am Coll Cardiol. 1986. PMID: 3958360
-
Animal models for protecting ischemic myocardium: results of the NHLBI Cooperative Study. Comparison of unconscious and conscious dog models.Circ Res. 1985 May;56(5):651-65. doi: 10.1161/01.res.56.5.651. Circ Res. 1985. PMID: 3838923
-
Relation between myocardial perfusion and left ventricular function following acute coronary occlusion: disproportionate effects of anterior vs. inferior ischemia.Circ Res. 1987 Jan;60(1):60-71. doi: 10.1161/01.res.60.1.60. Circ Res. 1987. PMID: 3568288
-
The pathophysiology of myocardial stunning: reversibility, accumulation and continuity of the ischemic myocardial damage after reperfusion.Jpn Circ J. 1991 Sep;55(9):868-77. doi: 10.1253/jcj.55.868. Jpn Circ J. 1991. PMID: 1658410
Cited by
-
Repeated short periods of regional myocardial ischemia: effect on local function and high energy phosphate levels.Basic Res Cardiol. 1986 Jul-Aug;81(4):361-72. doi: 10.1007/BF01907457. Basic Res Cardiol. 1986. PMID: 3778416
-
High-energy phosphates, myocardial contractile function and material properties after short periods of oxygen deficiency.Basic Res Cardiol. 1989 Jan-Feb;84(1):77-90. doi: 10.1007/BF01907005. Basic Res Cardiol. 1989. PMID: 2923609