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. 1983 Aug 12;221(4611):677-9.
doi: 10.1126/science.6867739.

Alcohol self-administration disrupts reproductive function in female macaque monkeys

N K Mello, M P Bree, J H Mendelson, J Ellingboe, N W King, P Sehgal

Alcohol self-administration disrupts reproductive function in female macaque monkeys

N K Mello et al. Science. .

Abstract

Female macaque monkeys self-administered high doses of alcohol (2.9 to 4.4 grams per kilogram per day) for 3 to 6 1/2 months. Amenorrhea, atrophy of the uterus, decreased ovarian mass, and significant depression of luteinizing hormone levels were associated with chronic alcohol intoxication. Reproductive system failure in female primates following self-induced dependence on alcohol parallels the results of clinical studies of alcoholic women.

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