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. 1978 Aug;37(4):315-20.
doi: 10.1136/ard.37.4.315.

Prostaglandin production in arthritis

R A Sturge, D B Yates, D Gordon, M Franco, W Paul, A Bray, J Morley

Prostaglandin production in arthritis

R A Sturge et al. Ann Rheum Dis. 1978 Aug.

Abstract

Inflammatory cell populations from synovial effusions or synovial villi in rheumatoid arthritis have been cultured in vitro. Prostaglandin productive capacity, measured by radioimmunoassay, showed the polymorphonuclear leucocyte rich populations from synovial effusions to be poor sources of PGE production whereas the synovial fragments produced substantial amounts of PGE activity. It is suggested that the macrophage is the major source of local prostaglandin formation both in gout and rheumatoid arthritis.

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References

    1. Bull Rheum Dis. 1958 Dec;9(4):175-6 - PubMed
    1. J Biol Chem. 1976 Dec 25;251(24):7816-20 - PubMed
    1. Ann Rheum Dis. 1976 Aug;35(4):327-32 - PubMed
    1. Br J Pharmacol. 1976 Jul;57(3):466P-467P - PubMed
    1. Annu Rev Biochem. 1975;44:669-95 - PubMed