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. 1983 Apr;13(2-3):255-7.
doi: 10.1007/BF01967346.

Histamine and histamine-N-methyltransferase in the CSF of patients with multiple sclerosis

L Tuomisto, H Kilpeläinen, P Riekkinen

Histamine and histamine-N-methyltransferase in the CSF of patients with multiple sclerosis

L Tuomisto et al. Agents Actions. 1983 Apr.

Abstract

The CSF of twenty-six patients with multiple sclerosis (MS) and of twelve control persons was analysed for histamine and histamine-N-methyltransferase (HMT) activity. Both in patients with remitting and progressive type of disease the histamine level was about 60% higher than in the controls. On the other hand in both groups of patients the HMT activity was significantly lower (32% and 40% respectively) than that of controls. These results suggest an altered histamine metabolism in MS. This might be associated with the immune reaction in MS brain.

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