Minimal change glomerular disease: a paraneoplastic syndrome in two patients with bronchogenic carcinoma

Abstract

Glomerulonephritis has often been reported as a paraneoplastic syndrome. In patients with carcinoma, the most common glomerular disease is membranous glomerulonephritis mediated presumably by immune complexes. Minimal change glomerular disease has been hitherto reported, to our knowledge, in only one patient with carcinoma. We report two patients with bronchogenic carcinoma in whom the simultaneous development of the nephrotic syndrome was due to minimal change glomerular disease.