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. 1983 May;38(4):239-46.
doi: 10.1111/j.1398-9995.1983.tb01617.x.

The non-specific enhancement of allergy. I. In vivo effects of Bordetella pertussis vaccine on IgE synthesis

R Pauwels, M Van der Straeten, B Platteau, H Bazin

The non-specific enhancement of allergy. I. In vivo effects of Bordetella pertussis vaccine on IgE synthesis

R Pauwels et al. Allergy. 1983 May.

Abstract

Bordetella pertussis organisms, with or without a small dose of alumhydroxide, enhance in rats the production of IgE antibodies to an unrelated antigen, even if this antigen has been administered 6 weeks beforehand. This non-specific enhancement of IgE antibodies is accompanied by a substantial rise in total serum IgE and by the production of IgE antibodies to B. pertussis. The effect of B. pertussis on IgE synthesis is dose-dependent. No effect of B. pertussis on IgE production can be observed in nude rats.

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