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Review
. 1977 Apr-Jun;128C(3):599-609.

The steering function of T cells in expression of the antibody repertoire directed against multideterminant protein antigen

E Sercarz, J M Cecka, D Kipp, A Miller
  • PMID: 68705
Review

The steering function of T cells in expression of the antibody repertoire directed against multideterminant protein antigen

E Sercarz et al. Ann Immunol (Paris). 1977 Apr-Jun.

Abstract

Limitation in the T-cell repertoire has the consequence of reducing the heterogeneity of antibody production. This has been demonstrated in three different systems, in which the T-cell restriction was imposed (1) by tolerance, (2) by peptide priming (3) by natural scarcity. Therefore, expressed repertoires may represent only a portion of the genetically prescribed V regions.

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