doi: 10.1016/0021-9150(83)90077-1.
Effect of high dose progestin on serum lipids
- PMID: 6870984
- DOI: 10.1016/0021-9150(83)90077-1
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Effect of high dose progestin on serum lipids
Atherosclerosis.
1983 Apr.
Abstract
The effect of high dose medroxyprogesterone (MPA) on serum lipids was studied in 31 postmenopausal patients with endometrial cancer. After 3 months of MPA treatment, total cholesterol decreased by 18% (P less than 0.001), LDL cholesterol by 16% (P less than 0.01) and HDL cholesterol by 38% (P less than 0.001) from the respective pretreatment values; correspondingly, the ratio of HDL to total cholesterol decreased (P less than 0.001). Similar changes were found as early as 2 weeks after start of treatment. In the 15 controls receiving no progestin treatment, full dose intracavitary radiotherapy and gynecological surgery had no effect on these serum lipids.
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