Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1983 Jul;48(1):27-34.
doi: 10.1038/bjc.1983.153.

Studies of the pharmacokinetic properties of nimorazole

J Overgaard, M Overgaard, A R Timothy
Free PMC article

Studies of the pharmacokinetic properties of nimorazole

J Overgaard et al. Br J Cancer. 1983 Jul.
Free PMC article

Abstract

The pharmacokinetics of the hypoxic radio-sensitizer nimorazole were studied in 19 individuals after single oral doses of between 0.5-3.5 g. HPLC measurements showed, after a rapid absorption, a linear relationship between peak plasma concentration and given dose. Mean elimination half life was 3.1 h. A tendency to a dose-dependent variation in the apparent volume of distribution, total body clearance and elimination half life suggest non-linear pharmacokinetics of nimorazole. Tumour concentrations measured in 5 patients gave tumour/plasma ratios between 0.8-1.3. No toxicity was observed. The results indicate that nimorazole may have potential as a clinically useful hypoxic radiosensitizer.

PubMed Disclaimer

References

    1. Biochem Pharmacol. 1971 Feb;20(2):339-49 - PubMed
    1. Br J Cancer. 1975 Jan;31(1):75-80 - PubMed
    1. Radiology. 1975 Oct;117(1):129-33 - PubMed
    1. Prensa Med Mex. 1975 Nov-Dec;40(11-12):378-82 - PubMed
    1. Br J Cancer Suppl. 1978 Jun;3:299-301 - PubMed

Publication types