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. 1983 May;79(1):6-8.
doi: 10.1111/j.1476-5381.1983.tb10486.x.

The effect of felodipine on ventricular fibrillation after coronary artery ligation in the anaesthetized pig

P D Verdouw, B H Wolffenbuttel

The effect of felodipine on ventricular fibrillation after coronary artery ligation in the anaesthetized pig

P D Verdouw et al. Br J Pharmacol. 1983 May.

Abstract

A 10 min ligation of the left anterior descending coronary artery in anaesthetized pigs resulted in ventricular fibrillation (VF) in 70% of control and propranolol-treated animals. Felodipine (10 nmol kg-1) not only reduced ventricular ectopic activity by 90%, but also completely abolished VF. When a second occlusion was applied after 20 min of reperfusion, felodipine was less effective against VF, possibly due to decreasing felodipine concentrations or only a transient increase in VF threshold.

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References

    1. Nature. 1981 Aug 20;292(5825):777-8 - PubMed
    1. Br J Pharmacol. 1981 Sep;74(1):12-4 - PubMed
    1. J Mol Cell Cardiol. 1982 Jan;14(1):21-32 - PubMed
    1. Am Heart J. 1982 Jun;103(6):973-7 - PubMed

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