Comparative Study
doi: 10.1016/0305-0491(83)90312-7.
2-Deoxyglucose as a substrate for glutathione regeneration in human and ruminant red blood cells
- PMID: 6872511
- DOI: 10.1016/0305-0491(83)90312-7
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Comparative Study
2-Deoxyglucose as a substrate for glutathione regeneration in human and ruminant red blood cells
Comp Biochem Physiol B.
1983.
Abstract
2-Deoxyglucose was found to be a substrate for the regeneration of GSH from GSSG in the red blood cells of humans, sheep, goats and cattle. The regeneration rate with 2-deoxyglucose varied from 15 to 56% of the rate with glucose. It is likely that 2-deoxyglucose is phosphorylated to 2-deoxyglucose-6-phosphate by HK and is then oxidized to 2-deoxygluconate-6-phosphate by G6PD. The latter reaction would produce the NADPH required for GSH regeneration.
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