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. 1983 May 20;90(1):121-3.
doi: 10.1016/0014-2999(83)90222-4.

Vasoactive intestinal polypeptide: presence in neuroblastoma X glioma hybrid cells

T Glaser, J Besson, G Rosselin, B Hamprecht

Vasoactive intestinal polypeptide: presence in neuroblastoma X glioma hybrid cells

T Glaser et al. Eur J Pharmacol. .

Abstract

Extracts of neuroblastoma X glioma hybrid cells 108CC15 and their parental lines were investigated for the presence of vasoactive intestinal polypeptide (VIP). With the aid of a radioimmunoassay and a receptor binding assay, VIP activity was found in the hybrid cells, to a lesser extent in neuroblastoma cells, but not in glioma cells. These results suggest a neuronal function of VIP. Since the hybrid cells also contain acetylcholine and opioids, they may be useful in studies of co-release of neurohormones.

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