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Clinical Trial
. 1978 Sep;6(3):243-6.
doi: 10.1111/j.1365-2125.1978.tb04592.x.

Clobazam--a new hypnotic?

C M Kesson, J M Gray, D H Lawson
Clinical Trial

Clobazam--a new hypnotic?

C M Kesson et al. Br J Clin Pharmacol. 1978 Sep.

Abstract

1 A double-blind randomized trial to compare the relative efficacy of the 1,5-benzodiazepine, clobazam, the 1,4-benzodiazepine nitrazepam, and placebo as hypnotics was carried out. 2 A preference technique was used and the analyses were performed sequentially. 3. The results confirmed that nitrazepam was superior to placebo as a hypnotic but failed to show that clobazam was superior to either placebo or nitrazepam in a ratio of 2:1. Thus, it seems likely that the hypnotic properties of clobazam are minimal. 4 Clobazam is not suitable for use as a hypnotic in hospitalized patients.

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