Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1978 Jul;38(1):130-6.
doi: 10.1038/bjc.1978.172.

Split dose cytotoxic experiments with misonidazole

I J Stratford
Free PMC article

Split dose cytotoxic experiments with misonidazole

I J Stratford. Br J Cancer. 1978 Jul.
Free PMC article

Abstract

The toxicity of misonidazole (1-(2-nitroimidazol-1-yl)-3-methoxy-2-propanol) towards mammalian cells in vitro has been determined as a function of O2 tension. Misonidazole under hypoxic conditions (less than 10 Parts/10(6) O2) shows the greatest toxicity. Split-dose experiments indicate that lethal damage can be "repaired" by O2, the magnitude of this repair being time dependent and a function of O2 concentration, with maximum repair in air seen after 2 h at 37 degree C. Unlike radiation damage this repair is not inhibited by modest hyperthermia (41 degrees C) during the split-dose interval. The implication of these results as regards the mechanism of misonidazole toxicity under anaerobic conditions is discussed.

PubMed Disclaimer

References

    1. Int J Radiat Biol Relat Stud Phys Chem Med. 1977 Mar;31(3):237-50 - PubMed
    1. Br J Cancer Suppl. 1978 Jun;3:129-31 - PubMed
    1. Int J Radiat Oncol Biol Phys. 1977 May-Jun;2(5-6):521-30 - PubMed
    1. Br J Cancer. 1977 Jun;35(6):809-15 - PubMed
    1. Br J Cancer. 1977 May;35(5):567-79 - PubMed