Problems in controlled trials--a critical response
- PMID: 6876103
- PMCID: PMC1059347
- DOI: 10.1136/jme.9.2.85
Problems in controlled trials--a critical response
Abstract
KIE: Responding to an article by R. Burkhardt and G. Kienle in the same issue of the Journal of Medical Ethics, Vere strongly disputes their criticisms of the controlled clinical trial. He maintains that the proper use of the statistical method in a randomized trial provides the 'best, most precise, and most conservative way' for a medical researcher to decide among alternative therapies, and that the individual patient benefits from participation in an experimental group. Burkhardt and Kienle defend their conclusions in a brief response to Vere's article, but he remains unconvinced in his own short reply to their comments.
Similar articles
-
Basic problems in controlled trials.J Med Ethics. 1983 Jun;9(2):80-4. doi: 10.1136/jme.9.2.80. J Med Ethics. 1983. PMID: 6876102 Free PMC article.
-
The ethics of randomised controlled trials: a matter of statistical belief?Health Care Anal. 1996 May;4(2):95-102. doi: 10.1007/BF02251209. Health Care Anal. 1996. PMID: 10162773
-
Science, ethics, and the making of clinical decisions. Implications for risk factor intervention.JAMA. 1988 Jun 3;259(21):3161-7. JAMA. 1988. PMID: 3285047 Review.
-
The ethics of placebo-controlled trials.Can J Psychiatry. 1995 May;40(4):165-6. doi: 10.1177/070674379504000401. Can J Psychiatry. 1995. PMID: 7621384 No abstract available.
-
Placebo-controlled studies in rheumatoid arthritis: ethical issues.Lancet. 1999 Jan 30;353(9150):400-3. doi: 10.1016/S0140-6736(98)01373-7. Lancet. 1999. PMID: 9950461 Review. No abstract available.
Cited by
-
Basic design considerations for clinical trials in oncology.Jpn J Cancer Res. 1992 Jun;83(6):547-58. doi: 10.1111/j.1349-7006.1992.tb00124.x. Jpn J Cancer Res. 1992. PMID: 1644658 Free PMC article. Review. No abstract available.
References
MeSH terms
LinkOut - more resources
Full Text Sources
Medical