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Comparative Study
. 1983 Aug 19;221(4612):766-9.
doi: 10.1126/science.6879174.

Multigene family for sarcomeric myosin heavy chain in mouse and human DNA: localization on a single chromosome

L A Leinwand, R E Fournier, B Nadal-Ginard, T B Shows
Comparative Study

Multigene family for sarcomeric myosin heavy chain in mouse and human DNA: localization on a single chromosome

L A Leinwand et al. Science. .

Abstract

Cloned myosin heavy chain DNA probes from rat and human were hybridized to restriction endonuclease digests of genomic DNA from somatic cell hybrids and their parental cells. The mouse myosin heavy chain genes detectable by this assay were located on chromosome 11, and three different human sarcomeric myosin heavy chain genes were mapped to the short arm of chromosome 17. A synteny between myosin heavy chain and two unrelated markers, thymidine kinase and galactokinase, was found to be preserved in the rodent and human genomes.

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