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. 1983 Aug 26;221(4613):871-3.
doi: 10.1126/science.6879185.

Morphine tolerance in genetically selected rats induced by chronically elevated saccharin intake

I Lieblich, E Cohen, J R Ganchrow, E M Blass, F Bergmann

Morphine tolerance in genetically selected rats induced by chronically elevated saccharin intake

I Lieblich et al. Science. .

Abstract

Rats of line LC2-Hi that drank about 50 milliliters of a highly palatable saccharin solution daily for 28 consecutive days did not show morphine analgesia or an opioid form of stress-induced analgesia and were not responsive to naloxone. These findings support the idea that chronically elevated saccharin intake may cause increased release and utilization of endogenous opiates.

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