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. 1983 Apr 30;59(4):469-75.

Evidence for a dose-dependent effect in the sex-specific plasma prolactin response to naloxone in humans

  • PMID: 6882542

Evidence for a dose-dependent effect in the sex-specific plasma prolactin response to naloxone in humans

P Monteleone et al. Boll Soc Ital Biol Sper. .

Abstract

In attempt to ascertain if the sex specific plasma PRL response to naloxone, that we suggested in previous studies, was a dose dependent effect, 26 healthy volunteers were studied. They received naloxone 2 mg and 4.8 mg or a volume matched of saline i.v. as a bolus. Blood samples were collected and plasma PRL was measured by double antibody RIA. Naloxone, at dose of 2 mg, was able to decrease significantly plasma PRL levels in normally menstruating women (p less than 0.05 at 60 min.; p less than 0.01 at 120 min.), but not in post-menopausal ones and in men. In addition, the dose of 4.8 mg of the drug did not change plasma PRL in any group. These results suggest a dose-dependent effect in the sex specific PRL response to naloxone in humans.

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